The ABATE Study is testing a vaccine for Alzheimer’s disease in people with Down syndrome. The study is being conducted in collaboration with the Alzheimer's Clinical Trials Consortium – Down Syndrome - ACTC-DS.
People with Down syndrome often get Alzheimer’s disease (a type of dementia) when they get older. Dementia is a disease that causes memory loss and other thinking problems. Dementia due to Alzheimer’s occurs when a protein called amyloid builds up in the brain. About 80 people with Down syndrome will take part in the ABATE Study. The study is testing an investigational vaccine for Alzheimer’s disease in people with Down syndrome. We want to see:
• If the vaccine is safe
• How the vaccine works inside the body
• If it helps get rid of amyloid buildups
• If it slows down memory loss and thinking problems
What is a clinical research study? Clinical studies test new drugs that are not available to be prescribed yet. They test to see if the drugs are safe and effective and don’t have too many side effects. Right now, there is no treatment available for Alzheimer’s disease and dementia in people with Down syndrome. Your participation in this study could help us find a treatment. To learn more, visit Abate-study.com or contact the study team: Blake Wilson 615-936-4997 blake.wilson@vumc.org